First-Line Immune Therapy—Implications for Pathologists

First-line treatment for hypertension

Published online 28 November 2001. Recent guidelines for hypertension management differ in their recommendations for routine firstline treatment for hypertension, as have previous generations of guidelines. For example, the United States JNC VI and British Hypertension Society guidelines both recommend low-dose diuretics and beta-blockers as first-line treatment unless there are compelling cont...

Majocchi’s granuloma: A common infection, uncommon for pathologists

Platelet desialylation correlates with efficacy of first-line therapies for immune thrombocytopenia

Immune thrombocytopenia (ITP) is a common autoimmune bleeding disorder. Despite considerable investigation, the pathogenesis of ITP remains incompletely understood, and for many patients, effective therapy is still unavailable. Using murine models and in vitro studies of human blood samples, we recently identified a novel Fc-independent platelet clearance pathway, whereby antibody-mediated desi...

First-Line First? Trends in Thiazide Prescribing for Hypertensive Seniors

BACKGROUND Evidence of reduced cardiovascular morbidity and mortality as well as cost support thiazide diuretics as the first-line choice for treatment of hypertension. The purpose of this study was to determine the proportion of senior hypertensives that received thiazide diuretics as first-line treatment, and to determine if cardiovascular and other potentially relevant comorbidities predict ...

First-line treatment for advanced pancreatic cancer.

Metastatic pancreatic cancer is a rapidly fatal disease with few therapeutic options. The authors summarize four abstracts (#148, #233, #158, #291) presented at the 2013 ASCO Gastrointestinal Cancers Symposium which were focused on novel agents for metastatic pancreatic cancer.